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. 2005 Aug 15;146(5):670–678. doi: 10.1038/sj.bjp.0706371

Figure 2.

Figure 2

Direct inflammatory effects of PAR4 activation in the mouse paw. The oedema formation (a) and granulocyte recruitment (b) were evaluated following an intraplantar injection of the PAR4-AP, AYPGKF-NH2 (50 μg), the control inactive peptide, YAPGKF-NH2 (50 μg), or the saline vehicle. The effect of a pepducin P4pal10 (0.25 mg kg−1) pretreatment was also evaluated against the oedema formation (c) and granulocyte recruitment (d) induced by AYPGKF-NH2 (50 μg) and YAPGKF-NH2 (50 μg). Values are mean±s.e.m. of n=5–8 per group. *Significantly different from the saline vehicle or the control peptide group (a and b), P<0.05; #significantly different from the vehicle+AYPGKF-NH2 group (c and d), P<0.05.