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Noninvolvement of NO and prostanoids in PAR4-mediated oedema formation and granulocyte recruitment in the mouse paw. Effect of indomethacin (cyclooxygenases inhibitor, 5 mg kg−1) or L-NAME (nitric oxide synthases inhibitor, 25 mg kg−1) on oedema formation (a) and on granulocyte recruitment (b) observed following PAR4 activation with AYPGKF-NH2 (50 μg). Values are mean±s.e.m. of n=8–9 per group. No statistically significant difference was observed between groups.
