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Role for neutrophils in the PAR4-mediated oedema formation in the mouse paw. A granulocyte-depleting antibody (anti-mouse Ly-6G antibody clone RB6-8C5, 125 μg) causes a marked reduction of myeloperoxidase, indicative of neutropenia (b) as well as reducing the oedema (a) mediated by AYPGKF-NH2 (50 μg) whereas a control antibody (rat IgG2bκ antibody, 125 μg) does not. Values are mean±s.e.m. of n=8 per group. *Significantly different from the vehicle+AYPGKF-NH2 group, P<0.05.
