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Role for the tissue and plasma kallikreins in PAR4-mediated oedema formation in the mouse paw. Effect of FE999024 (tissue kallikrein inhibitor, 60 μmol kg−1) or FE999026 (plasma kallikrein inhibitor, 60 μmol kg−1) on the oedema formation (a) and granulocyte recruitment (b) observed following PAR4 activation with AYPGKF-NH2 (50 μg). Values are mean±s.e.m. of n=8 per group. *Significantly different from the vehicle+AYPGKF-NH2 group, P<0.05.
