Figure 6.
Role for the kinin B2 receptor, but not the B1, in PAR4-mediated oedema formation in the mouse paw. Effect of SSR240612 (kinin B1 receptor antagonist, 10 mg kg−1) or of icatibant (kinin B2 receptor antagonist, 50 μg kg−1) on the oedema formation (a and b, respectively) and granulocyte recruitment (c) observed following PAR4 activation with AYPGKF-NH2 (50 μg). Values are mean±s.e.m. of n=8 per group. *Significantly different from the vehicle+AYPGKF-NH2 group, P<0.05; #significantly different from either the vehicle+saline or the icatibant+saline groups, P<0.05.