. 2005 Aug 22;146(5):642–653. doi: 10.1038/sj.bjp.0706372

Table 3.

Simulated average drug responses (expressed as percentages of the maximum possible average drug response, i.e., the response obtained with 10 mg kg⁻¹ meloxicam) for different end points and doses ranging from 0.1 to 1 mg kg⁻¹

	Average response (from 0 to 100%)						Meloxicam dose (mg kg⁻¹)
End point	E_0.1^a	E_0.2^a	E_0.3^a	E_0.4^a	E_0.5^a	E₁^a	ED₅₀^b	ED₇₀^b	ED₉₀^b
Skin temperature difference	0.05	3.60	23.9	49.8	70.6	98.4	0.40	0.50	0.67
Pain score	0.02	11.30	51.2	81.1	94.9	99.4	0.30	0.36	0.45
Body temperature	1.6	34.90	72.4	90.7	96.5	99.5	0.235	0.29	0.39
Lameness score	0.2	21.9	63.7	87.2	95.9	99.3	0.26	0.32	0.42
Overall locomotion variable	0.03	15.80	59.4	86.1	96.2	99.3	0.275	0.33	0.43

E_X (%) represents the predicted average drug response for a single s.c. dose of X mg kg⁻¹ meloxicam.

ED_Y (mg kg⁻¹) is the meloxicam dose producing Y% of the maximum possible average drug response that can be obtained with a single s.c. administration of meloxicam.