. 2005 Sep 5;146(5):723–731. doi: 10.1038/sj.bjp.0706381

Table 2.

Hemodynamic parameters in rats 18 weeks after sham surgery or myocardial infarction treated either with placebo, cariporide, ramipril or the combination of cariporide and ramipril

Parameter	Sham operation (n=14)	Myocardial infarction
		Placebo (n=11)	Cariporide (n=9)	Ramipril (n=9)	Carip/ram (n=11)
Heart rate (bpm)	366±8	355±5	377±12	344±7	374±13
LVSP (mmHg)	156±5	113±8^*	143±7^†	123±9^*	140±4^†
LVEDP (mmHg)	5±1	18±2^*	12±2^†	9±1^†q	11±1^†
LVESV (μl)	154±16	308±10^*	226±19^†	200±24^†	213±16^†
MAP (mmHg)	140±8	103±9^*	126±7^†	106±9^*	121±6^†
dp/dt_max (mmHg s⁻¹)	8618±435	5185±363^*	8077±525^†§	6332±527^†	7395±446^†
EF (%)	56±2	28±3^*	41±3^†	46±4^†	40±2^†
SW (mmHg μl⁻¹)	18,156±1099	6925±1033^*	15,231±1565^†	14,028±1864^†	12,577±1070^†
Ees (mmHg μl⁻¹)	0.64±0.05	0.35±0.06^*	0.40±0.06^§	0.30±0.05	0.47±0.08^†§
dp/dt_min (mmHg s⁻¹)	−7686±263	−4199±357^*	−4734±398	−5030±195^†	−4745±331
EDPVR (mmHg μl⁻¹)	0.0144±0.004	0.042±0.001^*	0.026±0.014^*^†	0.0098±0.004^†‡	0.012±0.003^†‡

Hemodynamic parameter in sham-operated rats (sham) and rats with congestive heart failure 18 weeks after myocardial infarction: effects of placebo, NHE-1 inhibition (cariporide), ACE inhibition (ramipril), or combined NHE-1 and ACE inhibition (Carip/ram). LVESP=left ventricular systolic pressure; LVEDP=LV end-diastolic pressure; LVESV=LV end-systolic volume; MAP=mean arterial pressure; EF=ejection fraction; dp/dt_max=maximal rate of pressure development; dp/dt_min; maximal rate of decay of pressure; SW=stroke work; Ees=end-systolic pressure volume relationship; EDPVR=end-diastolic pressure volume relationship. Values are mean±s.e.m. ^*P<0.05 vs sham, ^†P<0.05 vs placebo, ^§P<0.05 vs ramipril, ^‡P<0.05 vs cariporide.