Table 1.

Body weight, renal response to the water load and urinary excretion of sodium in baseline conditions in cirrhotic rats prior to receiving different doses of RWJ-351647 or vehicle

	Vehicle (n=5)	RWJ-351647 (0.5 mg kg−1) (n=5)	RWJ-351647 (1 mg kg−1) (n=5)	RWJ-351647 (2.5 mg kg−1) (n=5)
Body wt (g)	508±13	510±30	457±22	493±18
% Water load excreted	28±5	20±6	18±5	25±6
mUOsm (mOsm kg−1)	347±100	470±91	538±293	435±269
UNaV (μEq min−1)	0.40±0.1	0.2±0.08	0.18±0.06	0.2±0.09