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Body weight, renal response to the water load, serum sodium and serum osmolality in the cirrhotic rats after completing chronic treatment with RWJ-351647 or vehicle
| RWJ-351647 (n=6) | Vehicle (n=6) | |
|---|---|---|
| Body wt (g) | 517±37 | 533±29 |
| % Water load excreted | 92±21 | 33±13a |
| mUOsm (mOsm kg−1) | 156±72 | 314±122 |
| Serum sodium (mEq l−1) | 145±1 | 143±1 |
| Serum osmolality (mOsm kg−1) | 298±3 | 297±4 |
P<0.05 with respect to treated rats (unpaired Student's t-test).
