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. 2005 Sep 19;146(6):769–780. doi: 10.1038/sj.bjp.0706396

Figure 1.

Figure 1

Elements of HSF-1 activation: potential drug targets. The figure contains the major elements of the activation of HSF-1, the major transcription factor leading to the induction of Hsp synthesis. The potential drug targets are the following: (1) cytoplasmic complex of HSF-1 and Hsp90; (2) HSF-1 translocation to the nucleus; (3) intranuclear distribution of HSF-1; (4) nuclear complex of HSF-1 and Hsp90; (5) retrotranslocation of HSF-1 to the cytoplasm. RalBP-1, Ral-binding protein-1; p23, cochaperone of Hsp90.