Table 1.
Hsp modulator compounds (a few examples)
| Compound | Modulation | Targets | Potential indications | References |
|---|---|---|---|---|
| Carbenoxonole | Inducer | Hsp70 | Ulcer | Nagayama et al. (2001) |
| 2-Cyclopenten-1-one | Inducer | HSF-1 | Viral infections | Rossi et al. (1996) |
| Dexamethasone | Inducer | HSF-1 | Ischemic heart disease, inflammation | Sun et al. (2000) |
| Geranyl-geranyl acetone | Inducer | Hsp70 | Cerebral and cardiac ischemia | Ooie et al. (2001), Yasuda et al. (2005) |
| Paeoniflorin | Inducer | Hsp27, Hsp40, Hsp70 | Not identified yet | Yan et al. (2004) |
| Proteasome inhibitors | Inducer | Hsp70 | Neuro-degeneration | Kim et al. (2004) |
| Stannous chloride | Inducer | Hsp70 | Tissue transplantation | House et al. (2001) |
| Glycyrrhizin | Co-inducer | HSF-1 | Not identified yet | Yan et al. (2004) |
| Bimoclomol, arimoclomol, BRX-220 | Co-inducer | HSF-1, membranes | ALS, diabetic neurophaty, pancreatitis, ischemic heart disease | Vigh et al. (1997), Jednakovits et al. (2000), Kurthy et al. (2002), Rakonczay Jr. et al. (2002), Kieran et al. (2004) |
| Geldanamycin, 17AAG | Inhibitor | Hsp90 | Cancer | Whitesell et al. (1994), Neckers & Neckers (2005) |
| Radicicol, cyclo-proparadicicol | Inhibitor | Hsp90 | Cancer | Soga et al. (1998), Yang et al. (2004) |
| PU3, PU24F-Cl (purin-based molecules) | Inhibitor | Hsp90 | Cancer | Chiosis et al. (2001) |
| Dihydroxy-phenylpyrazole | Inhibitor | Hsp90 | Cancer | Kreusch et al. (2005) |
| Trichostatin-A (histone deacetylase inhibitors) | Inhibitor | Hsp90 | Cancer | Yu et al. (2002) |