Table 1.
Cardiac function and infarct size in hearts treated with cannabinoid agonists
| Perfusion time (min) | n | Diastolic pressure (mmHg) | LVDP (mmHg) | Coronary flow (ml min−1) | |
|---|---|---|---|---|---|
| Vehicle | 10 | 9±1 | 106±8 | 15±1 | |
| 15 | 13 | 8±1 | 100±6 | 14±1 | |
| 135 | 41±9 | 21±3 | 3±1 | ||
| Anandamide (1 μM) | 10 | 6±1 | 104±10 | 16±1 | |
| 15 | 7 | 5±2 | 111±11 | 18±1 | |
| 135 | 41±13 | 27±3 | 5±1 | ||
| Methanandamide (1 μM) | 10 | 9±2 | 95±20 | 12±1 | |
| 15 | 6 | 10±1 | 92±16 | 14±1 | |
| 135 | 27±5 | 21±5 | 3±1 | ||
| HU-210 (1 μM) | 10 | 5±2 | 104±11 | 11±1 | |
| 15 | 6 | 9±2 | 111±13 | 15±1 | |
| 135 | 47±6 | 17±3 | 3±1 | ||
| ACPA (1 μM) | 10 | 7±2 | 91±13 | 12±1 | |
| 15 | 6 | 11±2 | 87±10 | 13±1 | |
| 135 | 34±12 | 23±2 | 4±1 | ||
| JWH133 (1 μM) | 10 | 8±1 | 83±10 | 13±1 | |
| 15 | 8 | 11±1 | 89±16 | 13±1 | |
| 135 | 33±5 | 20±4 | 2±1 | ||
| ACPA+JWH133 (1 μM each) | 10 | 13±1 | 93±8 | 12±1 | |
| 15 | 9 | 12±2 | 94±6 | 13±1 | |
| 135 | 53±6 | 16±3 | 4±1 |
LVDP=left ventricular developed pressure.
Absolute values are given as mean±s.e.m. with n the number of hearts in the group.