Table 2.
Cardiac function and infarct size in hearts treated with cannabinoid agonists
| Time (min) | n | Diastolic pressure (mmHg) | LVDP (mmHg) | Coronary flow (ml min−1) | |
|---|---|---|---|---|---|
| Vehicle | 10 | 10±1 | 101±10 | 13±2 | |
| 15 | 7 | 9±2 | 96±9 | 13±1 | |
| 135 | 41±11 | 18±5 | 2±1 | ||
| Anandamide (1 μM) | 10 | 7±1 | 100±11 | 15±1 | |
| 15 | 7 | 7±2 | 103±11 | 17±1 | |
| 135 | 51±9 | 22±3 | 4±1 | ||
| Rimonabant (1 μM) | 10 | 13±2 | 88±6 | 12±2 | |
| 15 | 6 | 13±2 | 82±5 | 12±2 | |
| 135 | 56±6 | 15±3 | 2±1 | ||
| Rimonabant+ anandamide (1 μM each) | 10 | 12±1 | 81±3 | 13±1 | |
| 15 | 6 | 12±1 | 81±5 | 13±1 | |
| 135 | 53±6 | 22±1 | 3±1 | ||
| SR144528 (1 μM) | 10 | 9±2 | 113±9 | 15±1 | |
| 15 | 6 | 12±1 | 108±8 | 14±1 | |
| 135 | 58±9 | 14±3 | 5±2 | ||
| SR144528+ anandamide (1 μM each) | 10 | 9±1 | 98±5 | 18±1 | |
| 15 | 8 | 8±1 | 100±5 | 18±1 | |
| 135 | 22±8 | 26±5 | 5±1 |
LVDP=left ventricular developed pressure.
Absolute values are given as mean±s.e.m. with n the number of hearts in the group.