Table 1.

E_max and pD₂ values for ET1-induced contraction of endothelium-denuded rat carotid rings in the absence or presence of different concentrations of BQ123 and BQ788

Groups	Emax (g)	pD2
ET-1	0.63±0.02	8.95±0.12
ET-1+BQ123 (0.01 μM)	0.56±0.06	8.76±0.12
ET-1+BQ123 (0.1 μM)	0.49±0.05*	8.46±0.13*
ET-1+BQ123 (1 μM)	0.45±0.04*	8.03±0.22**
ET-1+BQ123 (3 μM)	0.37±0.03**	8.15±0.08**
ET-1+BQ788 (0.3 μM)	0.56±0.04	9.00±0.11
ET-1+BQ788 (1 μM)	0.50±0.07	8.59±0.08*
ET-1+BQ788 (3 μM)	0.44±0.05*	8.46±0.10*
ET-1+BQ123 (3 μM)+BQ788 (3 μM)	0.08±0.02**	—

Values are means±s.e.m. Six preparations were used in each group.

^*P<0.05 vs control (ET-1);

^**P<0.01 vs control (ANOVA).