Table 3.
Emax and pD2 values for IRL1620-induced relaxation of endothelium-intact rat carotid in the absence (Control) or presence of different drugs
| Groups | Emax (% relaxation) | pD2 | n |
|---|---|---|---|
| Control | 45.52±3.34 | 8.76±0.24 | 8 |
| L-NAME (100 μM) | 26.29±5.07* | 9.01±0.16 | 7 |
| ODQ (1 μM) | 27.79±5.27* | 9.11±0.06 | 7 |
| INDO (10 nM) | 22.93±7.16* | 8.87±0.60 | 6 |
| L-NAME (100 μM)+INDO (10 μM) | 13.57±3.78** | 8.75±0.10 | 6 |
| TEA (10 mM) | 24.02±3.90* | 8.63±0.18 | 7 |
| L-NAME (100 μM)+INDO (10 μM)+TEA (10 mM) | 7.24±3.70** | — | 6 |
| Sulfaphenazole (10 μM) | 40.01±3.10 | 8.55±0.20 | 5 |
| 4-AP (1 mM) | 18.62±6.95** | 8.48±0.42 | 8 |
| Apamin (1 μM) | 41.25±1.15 | 9.07±0.20 | 6 |
| Glibenclamide (3 μM) | 42.90±3.88 | 8.91±0.26 | 7 |
| Charybdotoxin(0.1 μM) | 47.99±7.87 | 8.79±0.14 | 6 |
Values are means±s.e.m. of n preparations.
*
P<0.05 vs Endo+;
**
P<0.01 vs Endo+ (ANOVA).