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Modified proarrhythmic scoring system to estimate a compound's risk for development of TdP in isolated rabbit left ventricular wedge preparation
| Parameter | Range | Score |
|---|---|---|
| QT interval increase (%) | ⩽10 | 0 |
| >10 to ⩽50 | 1 | |
| >50 to ⩽100 | 2 | |
| >100 | 3 | |
| TP–E (ms) | ⩽75 | 0 |
| >75 to ⩽90 | 1 | |
| >90 to ⩽120 | 2 | |
| >120 | 3 | |
| Phase 2 EAD | No EAD | 0 |
| EAD without R-on-T | 2 | |
| EAD with R-on-T | 4 | |
| EAD with TdP | 6 |
QT interval, TP–E, and EADs were scored independently and added up to a final score at a given concentration.
