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Effects of U 51605 in SHR isolated aortic rings. Concentration-dependent inhibition of U 46619-induced contraction in isolated aortic rings without endothelium by U 51605 (0.5, 1 and 3 μM; top). Effects of U 51605 (0.5, 1 and 3 μM) on the endothelium-dependent contractions to acetylcholine (presence of L-NA: 100 μM, bottom). Data are shown as mean±s.e.m. of at least five different experiments.
