Table 1.

EC₅₀ and % change in maximal ACh-evoked current in the presence of Aβ peptides in oocytes expressing recombinant nicotinic AChRs

	EC50 (μM)				%ΔImax (Ach)
	Control	Aβ1–42	Control	Aβ1–40	Aβ1–42	Aβ1–40
α7	390±87	413±97	261±66	206±22
	nH=1.3±0.1	nH=1.8±0.4	nH=1.9±0.2	nH=1.5±0.02	52.3±5***	54.8±10***
α4β2	5.0±1.8	12.1±4	3±0.4	8.1±3
1:1a	nH=1.6±0.2	nH=1.1±0.3	nH=2.1±0.4	nH=1.5±0.3	148.6±27	116.8±10
α4β2	360±75	229±67	477±74	363±107
1:1b	nH=1.0±0.14	nH=4.7±2.3	nH=1.1±0.1	nH=0.8±0.2	194.6±40***	194.8±41***
α4β2	47±22	21±11
1:9	nH=0.92±0.4	nH=0.94±0.1			128.8±11
α4β2	165±41	281±120
9:1	nH=0.94±0.1	nH=0.6±0.05			162.3±39***
α3β4	509±77	404±61	387±88	412±81
	nH=1.4±0.1	nH=1.4±0.1	nH=1.4±0.1	nH=1.3±0.1	96.0±1.2	99.1±7

^*P<0.05;

^**P<0.01;

^***P<0.001.

Using a two-way repeated measures ANOVA with Bonferroni post-test. n⩾6.

Abbreviations: %ΔI_max(ACh): Peptide induced percentage changes in maximal evoked ACh currents expressed relative to a control application of 3 mM ACh.

n_H: Hill coefficient.

^aHigh affinity subpopulation.

^bLow affinity subpopulation.