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. 2005 Dec 12;147(3):289–297. doi: 10.1038/sj.bjp.0706590

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Concentration-dependent effect of CLT on I_Kur. (a) I–V relationships of I_Kur during control, in the presence of CLT at 5 and 10 μM, and after washout. CLT inhibited I_Kur in a concentration–dependent manner, and the effect was partially reversed by 77.1% upon drug washout. (b) Concentration–response relationship of I_Kur inhibition by CLT at +50 mV. Symbols are the mean values of inhibiting effect in cells exposed to different concentrations. Solid lines are the best-fit Hill equation. IC₅₀ was 7.4 μM, b was 1.8, and E_max was 87.1%. The numbers in parentheses are numbers of experiments.