Figure 6.

Effect of the oral treatment with TR14035 (3 mg kg⁻¹, 1 h before and 3 h after antigen challenge), an α₄β₁/α₄β₇ dual antagonist, on IL-4-induced leukocyte rolling flux (a), leukocyte rolling velocity (b), leukocyte adhesion (c) and leukocyte emigration (d) in Brown Norway rat mesenteric postcapillary venules. Parameters were measured 24 h after i.p. injection of 5 ml of saline or 5 ml of IL-4 (1 μg/rat) in the following experimental groups: untreated rats exposed to saline (negative control); TR14035 treated rats exposed to saline; untreated rats exposed to IL-4 (positive control); and IL-4-exposed rats treated with TR14035. Data are mean±s.e.m. of 7–8 animals per group; ^*P<0.05 or ^**P<0.01 compared to negative control; ⁺P<0.05 or ⁺⁺P<0.01 compared to positive control.