Table 1.

Effects of pacing rate, BaCl₂ and (−) chromanol 293B on APD₉₀ in beagle dog Purkinje fibres

Treatment	Stimulation rate (Hz)	Sex	% Change in APD90	n	Number of animals
Krebs buffera	3.33	Male	−38.2±1.7	17	16
		Female	−36.9±2.0NS	19	17
	0.2	Male	11.0±1.2	31b	24
		Female	16.2±1.3*	32b	28
BaCl2 (10 μM)c	3.33	Male	8.0±1.2	5	4
		Female	7.0±0.9NS	6	4
	1.0	Male	12.2±3.0	5	5
		Female	11.4±1.9NS	6	5
	0.2	Male	18.6±4.0	5	5
		Female	14.7±3.9NS	6	5
(−) chromanol 293B (10 μM)c	3.33	Male	−0.6±1.2	4	4
		Female	−0.2±0.6NS	4	4
	1.0	Male	−0.2±0.7	4	4
		Female	1.4±1.3NS	4	4
	0.2	Male	0.2±1.3	4	4
		Female	1.8±2.2NS	4	4

APD₉₀: the duration of action potential at 90% repolarisation. Data are expressed as mean±s.e.m.

^aData are expressed as a per cent change relative to APD₉₀ at 1.0 Hz in Krebs buffer.

^bData were obtained in this study and Abi-Gerges et al. (2004a).

^cData are expressed as a per cent change relative to APD₉₀ at the same stimulation rate in Krebs buffer.

^NSP>0.05

^*P<0.01 versus values from male animals.