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. 2007 Jan 15;92(2):683–695. doi: 10.1529/biophysj.106.088021

FIGURE 2.

FIGURE 2

(A) Firing properties of LTS cells. (a) Membrane responses for five increasingly negative current steps (from −10 to −50 pA). Hyperpolarizing current injection (−50 pA) leads to a rebound spike. (b) Repetitive firing for four different current steps of increasing amplitude (20–260 pA). LTS cells support low firing frequency. (B) (a) Instantaneous firing frequency (1/interspike interval) versus time after the onset of current pulse at four selected current strengths (100, 140, 200, and 300 pA). LTS cells show strong adaptation at higher current strength (i.e., 300 pA), but little adaptation at lower current strength (i.e., 100 pA). (b) LTS neuron firing frequency versus injected current (f-I) relationship. Frequencies corresponding to the 1st, 2nd, 4th, and last spike intervals increased monotonically with the current strength, starting from 2 to 4 spikes/s, as low as could be assessed with this stimulus duration. This result indicates that LTS cells effectively have “type 1” threshold dynamics.