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Superimposition of active site residues of (yellow) W5A-H64W HCA II showing the binding site of 4-MI, and (orange) the side chains of His-64 and Trp-5 in HCA II (PDB accession code: 1TBT (10)) showing the inward and outward conformations of His-64, and (cyan) the binding site of 4-MI associated with the side chain of Trp-5 in H64A HCA II (PDB accession code: 1MOO; (16)). The figure was generated and rendered with BobScript and Raster3D (42,43).
