Fig. 2.
Mineral ion accumulation in the presence and absence of modulators of apoptosis. The induction of apoptosis with 40 nM staurosporine (4P + S) from day 7 caused an immediate 45Ca uptake that declined relative to control mineralizing cultures (4P). Cultures in which apoptosis was inhibited with 50 mM Z-VAD-fmk had apparently higher but not significantly greater 45Ca accumulation per culture. Values were normalized to day 21 4P values and are mean ±SD for n = 5-7 independent experiments. *P < 0.05 relative to untreated mineralizing control cultures (4P).