Figure 4.

Illustration of some similarities and distinctions in molecular regulation of detrusor and corporal myocyte tone. In this diagram, targets that are apparently more important to the regulation of the detrusor myocyte are shown in red (RyR receptor and SERCA), while those thought to be more important to the regulation of corporal smooth muscle are shown in yellow (PDEV/cGMP/nitric oxide pathway). If a target is important to both cell types, then it appears orange (BK_Ca, L-type calcium channel, gap junctions, Rho Kinase). Such observations may point the way to novel therapeutic possibilities.