Table 1.

Effects of Rho-kinase inhibition on contractile properties of bovine tracheal smooth muscle preparations following administration of muscarinic receptor agonists

	Vehicle		Y-27632
	pEC50 (−log M)	Emax (g)	pEC50 (−log M)	Emax (g)
Methacholine	6.73±0.15	25.4±2.5	6.19±0.15**	24.2±2.4
after PrBCm	3.59±0.14	21.8±1.2	2.91±0.17*	16.3±1.6*
Pilocarpine	6.52±0.08	22.2±3.6	6.09±0.02*	17.1±3.1*
McN-A-343	5.26±0.09	21.3±0.2	4.93±0.04*	10.5±1.7*

Data represent means±s.e.m. of 3–7 experiments, each performed in duplicate.

^*P<0.05

^**P<0.01 vs vehicle-treated.