Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Two models for the function of the 2TM proteins. In the upper panel (A) the proteins participate in formation of a multi-subunit, multi-TM solute pore. An alternative model is proposed in which the 2TM proteins modulate endogenous erythrocyte solute channels. In the lower panel (B) the proteins form the knob structure containing PfEMP1 proteins and mediating cytoadherence. A third model might integrate the knob and solute pore and knobs into a single erythrocyte surface structure.
