Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Acetylation of GR. Binding of a corticosteroid to GR results in its acetylation by HAT, such as CBP, and a dimmer of acetylated GR then binds to GRE to activate or suppress genes (such as side effect genes). Deacetylation of GR by HDAC2 is necessary for GR to interact with CBP and inhibit NF-κB to switch off inflammatory genes.
