Table 2.
Effects of PF on the mRNA upregulation of proinflammatory molecules induced by MPTP
| Saline | MPTP | PF (5 mg kg−1)+MPTP | DPCPX (0.3 mg kg−1)+PF (5 mg kg−1)+MPTP | |
|---|---|---|---|---|
|
VM | ||||
| iNOS |
1.00±0.17 |
2.98±0.50** |
1.02±0.17## |
2.23±0.37$ |
| TNF-α |
1.00±0.17 |
2.69±0.45** |
1.12±0.19## |
1.74±0.29 |
| IL-1β |
1.00±0.09 |
5.26±0.84** |
2.12±0.03## |
3.51±0.14$$ |
| |
|
|
|
|
|
Striatum | ||||
| iNOS |
1.00±0.03 |
1.95±0.32* |
1.17±0.27 |
1.68±0.07 |
| TNF-α |
1.00±0.08 |
3.17±0.26** |
1.30±0.02## |
2.63±0.03$$ |
| IL-1β | 1.00±0.18 | 1.42±0.06* | 1.06±0.17 | 1.24±0.04 |
All data were normalized to the GADPH mRNA level and expressed as RFC±s.e.m. (n=8).
P<0.05,
P<0.01 compared with saline-treated mice;
P<0.01 compared with MPTP-treated mice;
P<0.05,
P<0.01 compared with PF (5 mg kg−1)+MPTP-treated mice (one-way ANOVA followed by Dunnett's post hoc comparison).