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. 2006 Apr 3;148(3):314–325. doi: 10.1038/sj.bjp.0706732

Table 2.

Effects of PF on the mRNA upregulation of proinflammatory molecules induced by MPTP

  Saline MPTP PF (5 mg kg−1)+MPTP DPCPX (0.3 mg kg−1)+PF (5 mg kg−1)+MPTP
VM
 iNOS
1.00±0.17
2.98±0.50**
1.02±0.17##
2.23±0.37$
 TNF-α
1.00±0.17
2.69±0.45**
1.12±0.19##
1.74±0.29
 IL-1β
1.00±0.09
5.26±0.84**
2.12±0.03##
3.51±0.14$$
 
 
 
 
 
Striatum
 iNOS
1.00±0.03
1.95±0.32*
1.17±0.27
1.68±0.07
 TNF-α
1.00±0.08
3.17±0.26**
1.30±0.02##
2.63±0.03$$
 IL-1β 1.00±0.18 1.42±0.06* 1.06±0.17 1.24±0.04

All data were normalized to the GADPH mRNA level and expressed as RFC±s.e.m. (n=8).

*

P<0.05,

**

P<0.01 compared with saline-treated mice;

##

P<0.01 compared with MPTP-treated mice;

$

P<0.05,

$$

P<0.01 compared with PF (5 mg kg−1)+MPTP-treated mice (one-way ANOVA followed by Dunnett's post hoc comparison).