Table 4.
The properties of GW627368X in functional isolated tissue bioassays at prostanoid receptors (n=3)
|
Receptor |
EP2 |
EP4 |
TP |
|---|---|---|---|
| Agonist | PGE2 | PGE2 | U46619 |
| Rabbit saphenous vein |
<5.0 |
— |
<5.0 |
| Piglet saphenous vein |
— |
9.2±0.1a |
<5.0 |
| Guinea-pig aorta |
— |
— |
<5.0 |
| Washed human platelets |
— |
— |
0% inhibition at 1 μM |
| 100% inhibition at 10 μM |
Activity at prostanoid EP4 receptors in piglet saphenous vein has been previously published (Wilson & Giles, 2005) but is included here for completeness. Values are pA2 excepta=pKb.