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. 2006 Apr 3;148(3):340–349. doi: 10.1038/sj.bjp.0706729

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Copyright 2006, Nature Publishing Group

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Effects CPA on spontaneous Ca transients in circular smooth muscle of the rabbit urethra. (Aa) Spontaneous Ca transients in a circular smooth muscle strip. CPA (10 μM) initially increased the frequency of Ca transients but then abolished them. (Ab) After washing out CPA, spontaneous Ca transients were restored. (Ba) In another preparation, spontaneous Ca transients were generated, and CPA increased their frequency and amplitude. (Bb) In the same preparation that had been exposed to CPA for 30 min, Ca transients with increased amplitude and duration were generated. (Bc) With a fast time scale, Ca transients in the presence of CPA (dotted line) had a larger amplitude and longer duration than in control solution (full line). (Ca) In a preparation that generated CPA-resistant spontaneous Ca transients, (Cb) nicardipine (1 μM) dramatically diminished Ca transients. (Cc) Subsequent CPA abolished the residual Ca transients.