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(a) Concentration–response curves to NTG in wt mice aortas. Preparations were precontracted with U-46619 (10−7 M) and NTG was given cumulatively. *P<0.05 versus control and †P<0.05 versus rosuvastatin–NTG. Results are expressed as mean±s.e.m. (b) Concentration–effect curve to NTG in eNOS−/− mice aortas. Preparations were precontracted with U-46619 (10−7 M) and NTG was given cumulatively. *P<0.05 versus control and †P<0.05 versus rosuvastatin–NTG. Results are expressed as mean±s.e.m.
