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. Author manuscript; available in PMC: 2007 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2006 Oct 14;1761(12):1401–1409. doi: 10.1016/j.bbalip.2006.09.018

Fig 5. Analysis of serum total cholesterol and triglycerides in wild-type, FXR-null, ApoE-null and FXR/ApoE double-null mice.

Fig 5

FXR/ApoE double-null mice were generated by cross-breeding of FXR-null and ApoE-null mice. Serum was collected from male and female animals fed with a control diet at 20 weeks of age, or a high-fat diet for 10 weeks at 13 weeks of age. The grey bar represents male mice and the striped bar for female mice. (A) is for serum total cholesterol on control diet, (B) is for serum total cholesterol on high-fat diet, (C) is for serum total triglyceride on control diet, and (D) is for serum total triglyceride on high-fat diet. The cholesterol concentrations, in mg/dL, for the control and high-fat fed male and female wild-type mice were: male wild-type = 52.9 +/− 3.4, female wild-type = 36.3 +/− 2.2 for the control diets, and male, wild-type = 92.5 +/− 9.3, female, wild-type = 64.1 +/− 5.0 for the high-fat diets. The triglyceride concentrations, in mg/dL, for the control and high-fat fed male and female wild-type mice were: male wild-type = 49.7 +/− 5.5, female wild-type = 37.1 +/− 3.2 for control diets, and male wild-type = 51.1 +/− 3.8, female wild-type = 36.8 +/− 4.6 for the high-fat diets. Data from each group are derived from 8 to 14 mice. An asterisk indicates P<0.05 between FXR-null and FXR/ApoE double-null mice. A # indicates P<0.05 between ApoE-null and FXR/ApoE double-null mice.