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Relaxant effect of acetylcholine (a, b) and sodium nitroprusside (c, d) in extrapulmonary (a, c) and intrapulmonary (b, d) arteries from wild-type mice exposed or not to hypoxia. In each panel, the response is expressed as the percentage of relaxation of the tone induced by PGF2α. *P<0.05, ***P<0.001: significant difference compared to normoxia (ANOVA). n=15–53 (a, b) or 5–12 (c, d).
