Figure 4.
Effects of butyrate and chol-but SLN on PMN adhesion to FCS-coated plastic wells. PMNs were incubated with increasing concentrations (10−8–10−5 M) of the tested compound and with 10−7 M FMLP and seeded on 24-well EC-free plates for 10 min at 37°C. Data are expressed as percentage inhibition of control adhesion, as means±s.e.m.; n=5. Asterisks mark statistically significant inhibition of chol-but SLN versus butyrate (**P<0.001). Control adhesion (i.e. adhesion in the absence of FMLP) was 108±32 cells microscope−1 field (mean±s.e.m., n=5), adhesion induced by 10−7 M FMLP was 378±25% of the control.