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. 2006 May 15;148(5):619–628. doi: 10.1038/sj.bjp.0706770

Figure 5.

Figure 5

Effect of KCl on GW9508-potentiatiation of insulin secretion. Potentiation of KCl-stimulated insulin secretion in the presence of GW9508 at 25 mM glucose. In the presence of 25 mM glucose, insulin release was significantly potentiated by either 10 μM GW9508 or 30 mM KCl **P<0.01 vs 25 mM glucose-treated MIN6 cells;n=3). The presence of GW9508 (10 μM) significantly enhanced KCl or GW9508-stimulated insulin secretion in the presence of 25 mM glucose (++P<0.01 vs KCl or GW9508-treated MIN6 cells; n=3). Addition of the antagonist GW1100 (1 μM) prevented the effect of GW9508 on KCl or GW9508-mediated insulin release (##P<0.01 vs GW9508 and KCl-treated MIN6 cells; n=3). Data represent mean±s.e.m. Analysis of results was by ANOVA, followed by Tukey–Kramer multiple comparison test.