Table 3.
Comparison between experimental and simulated IC50 values over-time
|
Time (min) |
Atropine pIC50 (Log M) |
Tiotropium pIC50 (Log M) |
||
|---|---|---|---|---|
| Experimental | Simulated | Experimental | Simulated | |
| 5 |
9.04±0.06 |
9.34±0.003 |
8.52±0.03 |
8.62±0.002 |
| 10 |
9.11±0.05 |
9.33±0.009 |
8.75±0.02 |
8.84±0.01 |
| 15 |
9.20±0.06 |
9.24±0.01 |
8.82±0.02 |
8.94±0.009 |
| 20 |
9.11±0.02 |
9.15±0.01 |
8.90±0.02 |
8.90±0.01 |
| 25 |
8.99±0.04 |
9.07±0.01 |
8.87±0.02 |
9.00±0.01 |
| 30 |
8.97±0.01 |
9.01±0.01 |
8.88±0.02 |
9.06±0.01 |
| 45 |
8.87±0.03 |
8.88±0.01 |
8.92±0.01 |
9.14±0.01 |
| 60 |
8.78±0.03 |
8.80±0.01 |
8.97±0.01 |
9.20±0.01 |
| 120 |
8.69±0.03 |
8.69±0.01 |
9.16±0.02 |
9.38±0.01 |
| 180 |
8.62±0.02 |
8.67±0.01 |
9.31±0.03 |
9.50±0.01 |
| 360 |
8.60±0.05 |
8.66±0.01 |
9.64±0.03 |
9.69±0.01 |
| 1080 |
8.63±0.02 |
8.66±0.01 |
9.97±0.01 |
9.93±0.02 |
| 1200 | 8.65±0.02 | 8.66±0.01 | 9.98±0.04 | 9.94±0.008 |