Figure 4.

Effect of CaM on PDBu-evoked and constitutively active SOC activity in inside-out patches. (a) Bath application of 1 μM PDBu evoked channel activity that was initially inhibited and then increased by coapplication of 100 nM CaM. The insets (i) and (ii) show that the channel currents had similar unitary amplitudes. The multiple peaks represent openings of more than one SOC channel in the patch. (b) Mean data showing that CaM produced a dual effect on PBDu-evoked (n=8) and spontaneous SOC activity (n=5) composed of an initial inhibition of channel activity after 1 min followed by an increase in activity after 5 min (^*P<0.05).