Table 1.
Physiological parameters
| Parameter | UNX 4 week | UNX+ AG | DOCA-salt 4 week | DOCA-salt+AG |
|---|---|---|---|---|
| Systolic blood pressure (mmHg) |
128±5 (12) |
117±3* (11) |
176±4* (11) |
144±5** (12) |
| Initial body weight (g) |
326±3 (17) |
338±8 (21) |
341±8 (17) |
344±6 (26) |
| Final body weight (g) |
431±8 (17) |
440±10 (19) |
354±10* (16) |
369±5 (21) |
| LV+septum weight (mg g−1 bodywt) |
1.97±0.04 (15) |
2.08±0.04 (12) |
3.17±0.07* (14) |
2.66±0.08* (10) |
| RV weight (mg g−1 bodywt) |
0.57±0.02 (15) |
0.53±0.02 (12) |
0.65±0.02* (14) |
0.56±0.03* (10) |
| Thoracic aortic wall thickness (μm) |
123±4 (6) |
121±5 (8) |
157±6* (7) |
145±5* (8) |
| LV interstitial inflammation (grade) |
0.8±0.4 (5) |
0.8±0.4 (5) |
2.8±0.4* (5) |
2.8±0.6* (5) |
| LV interstitial area of collagen (%) |
2.71±0.21 (7) |
4.06±0.77 (8) |
14.43±1.75* (8) |
10.96±1.42* (8) |
| Diastolic stiffness (κ) |
22.2±1.2 (12) |
19.4±0.9 (12) |
30.1±1.2* (12) |
24.3±1.2** (10) |
| +dP/dTmax (mmHg s−1) |
2080±70 (8) |
2340±130* (12) |
1610±130* (13) |
2370±100** (10) |
| −dP/dTmax (mmHg s−1) |
−1590±50 (9) |
−1550±60 (12) |
−1320±70* (12) |
−1480±40** (10) |
| LVPWd (mm) |
1.5±0.1 (15) |
1.7±0.1* (11) |
2.0±0.1* (14) |
2.0±0.1* (14) |
| LVIDd (mm) |
6.8±0.2 (17) |
7.1±0.3 (13) |
6.6±0.2 (15) |
6.6±0.2 (15) |
| Ejection fraction (%) |
91.0±1.5 (16) |
92.6±1.4 (13) |
93.8±0.9 (15) |
93.3±1.4 (15) |
| Ascending aortic arch diameter (mm) |
3.3±0.1 (7) |
3.6±0.1* (12) |
2.9±0.1* (5) |
3.3±0.1** (14) |
| APD20 (ms) |
6.8±1.1 (8) |
6.9±1.1 (4) |
10.1±1.5* (7) |
10.7±1.0* (4) |
| APD50 (ms) |
16.4±2.0 (8) |
22.8±4.9 (4) |
19.8±2.7 (7) |
42.4±6.2** (4) |
| APD90 (ms) | 34.4±3.5 (8) | 38.4±7.7 (4) | 59.1±10.3* (7) | 76.8±11.2* (4) |
All values shown represent the mean±s.e.m. (n-value); AG=aminoguanidine, LV=left ventricular, RV=right ventricular, LVPWd=left ventricular posterior wall thickness in diastole; LVIDd=left ventricular internal diameter in diastole; APD=action potential duration at 20, 50 or 90% of repolarization. Significance:
*
P<0.05 vs UNX rats;
**
P<0.05 vs DOCA-salt rats.