Table 1.

Adjusted HRs (95% CI) of developing diabetes by baseline ECG indices and treatment arm

	Placebo	Metformin	Lifestyle
Heart rate (per 11 bpm)
Model 1	1.13 (1.01–1.27)	1.17 (1.03–1.34)	1.27 (1.08–1.49)
Model 2	1.09 (0.97–1.22)	1.17 (1.03–1.35)	1.19 (1.02–1.40)
SDNN (per 19 ms)
Model 1	1.01 (0.90–1.14)	0.88 (0.74–1.05)	0.94 (0.79–1.14)
Model 2	1.04 (0.91–1.18)	0.90 (0.76–1.06)	0.99 (0.82–1.18)
rMSSD (per 24 ms)
Model 1	0.99 (0.87–1.11)	0.87 (0.72–1.04)	0.87 (0.71–1.08)
Model 2	1.01 (0.88–1.18)	0.90 (0.76–1.06)	0.89 (0.73–1.08)
QTc (per 18 ms)
Model 1	1.06 (0.94–1.20)	1.09 (0.95–1.25)	1.08 (0.93–1.26)
Model 2	0.98 (0.86–1.11)	1.10 (0.96–1.27)	0.96 (0.81–1.14)
QTI (per 4%)
Model 1	1.02 (0.90–1.15)	1.02 (0.88–1.17)	1.02 (0.87–1.20)
Model 2	0.95 (0.84–1.08)	1.03 (0.89–1.19)	0.91 (0.76–1.09)

Model 1 adjusted for age, race, and sex. Model 2 adjusted for model 1 + baseline weight and weight change (per 4.5 kg) over follow-up.