Figure 2.

(a) MPO activity is significantly increased in the ileum of SAO/R rats. RLX, but not iRLX, significantly reduces MPO activity. Significance of differences (one-way ANOVA): ^*P<0.01 vs SAO/R+vehicle and SAO/R+iRLX. (b) Representative histopathological features of the ileum in sham-operated rats and SAO/R rats treated with vehicle or RLX. Severe mucosal abnormalities, consisting of truncated, edematous villi, hemorrhage foci and loss of surface and gland epithelium, can be seen in SAO/R+vehicle rats. These abnormalities are absent in SAO/R+RLX rats.