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Group assignments and dose levels
| Species | No of animals in group | Dose level (mg kg−1) | Dose concentration (mg ml−1) | Dose volume (ml) |
|---|---|---|---|---|
| CD-1 mouse | 15 | 1 | 0.3 | 0.1 |
| CD-1 mouse | 15 | 10 | 3.1 | 0.1 |
| Sprague–Dawley rat | 4 | 1 | 1 | 0.25 |
| Sprague–Dawley rat | 4 | 10 | 10 | 0.25 |
| Cynomolgus monkey | 4 | 1 | 1 | 1–2 |
| Cynomolgus monkey | 6 | 10 | 10 | 1–2 |
