Table 2.

Calculated pharmacokinetic parameters^a

	Mouse		Rat		Monkeyb
	1 mg kg−1	10 mg kg−1	1 mg kg−1	10 mg kg−1	1 mg kg−1	10 mg kg−1
BW (kg)	0.031±0.002	0.032±0.002	0.239±0.015	0.235±0.008	1.68±0.17	1.67±0.08
AUC (μg day−1 ml−1)	58.2	961	88.1±12	845±110	17.9±3.2	947±170
Cmaxc (ml day−1 kg−1)	21	211	17.9±1.4	173±20	16.9±1.2	199±24
CL (ml day−1 kg−1)	17.2	10.4	12.0±1.5	12.8±2.3	57.7±13	10.8±1.8
β1/2d	5.34	8.23	8.74±1.4	8.57±1.5	1.15±0.30	6.77±1.7
Vss (ml kg−1)	124	115	145±17	148±13	87.1±11	96.7±15

^aParameters calculated using compartmental analysis.

^bParameters calculated from SGN-40 profiles after the first dose administration (days 1–7).

^cC_max is the model-predicted maximum serum concentration of SGN-40.

^dFor rats and monkeys values are given as mean (±s.d.).