Figure 3.

Effect of agonist combination on characteristics of burst pattern responses. Effect of increasing doses of agonists on: (a) number of burst pattern responses after a single administration, (b) latency to initiation of burst pattern responses, measured as the time from administration to the first burst of the initial response, (c) mean maximum VDN firing frequency during synchronous bursts and (d) total duration of responses, measured as the time from administration to the end of the final PCA response. ^*P<0.05, ^**P<0.01, ^***P<0.001. n=4 for all groups.