Table 2.
Hepatic transaminases following carbon tetrachloride (CCl4) administration
| n | AST | ALT | AP | |
|---|---|---|---|---|
| A2A+/+ | 5 | 708±191 | 48±23 | 36±15 |
| A2A−/− | 14 | 129±22 | 37±9 | 163±45 |
| A2A+/+ + CCl4 | 6 | 380±81 | 130±25 | 90±24 |
| A2A−/− + CCl4 | 21 | 1178±449* | 308±78* | 200±36 |
| Control+CCl4 | 5 | 344±60 | 349±72 | 156±19 |
| Caffeine+CCl4 | 5 | 309±49 | 431±122 | 40±22 |
| Enprofylline+CCl4 | 4 | 181±20 | 142±12 | 133±48 |
| ZM-241385+CCl4 | 5 | 569±76** | 870±177** | 45±19 |
Serum AST, ALT and alkaline phosphatase (AP) values of experimental animals following treatment with vehicle or CCl4 were determined in serum obtained at killing after treatment with CCl4, as described in Methods.
*P<0.05 vs A2A−/− treated with vehicle or A2A+/+ mice treated with CCl4, two-way analysis of variance with Dunn's post hoc analysis.
**P<0.001, vs control mice, two-way analysis of variance with Dunn's post hoc analysis.