Table 2.
Distribution of NPBW1 and its homologue in human, mouse and rat
Human | Mouse | Rat | ||
---|---|---|---|---|
NPBW1 | NPBW2 | NPBW1 | NPBW1 | |
CNS tissues | ||||
Cerebellum | −a | +a | −b,c | −a,b,c |
Cerebral cortex | ND | ND | −b,c | +a,b,c |
Parietal cortex | −a | ++a | −b,c | −c |
Hippocampus | +++a | +++a | +b,c | +a,b,c |
Amygdala | +++a | +++1 | +++b,c | +++a,b,c,d |
Hypothalamus | −a | −a | +++b,c | +++a,b,c,d |
Thalamus | +a | ++a | +b,c | ++a,b,c |
Caudate nucleus | −a | ++a | −b,c | −c |
Substantia nigra | +a | +a | −b,c | −c |
Corpus callosum | +a | +a | −b,c | −c |
Bed nucleus of the stria terminalis | ND | ND | ++b,c | +++c |
Dorsal vagal complex | ND | ND | −b,c | ++c |
Periaqueductal grey | ND | ND | −b,c | ++c |
Superficial grey layer of superior colliculus | ND | ND | −b,c | ++c |
Medulla oblongata | ND | ND | ND | ++a |
Spinal cord | −a | −a | ND | ++a |
Peripheral tissues | ||||
Pituitary gland | ++a,b | ++a | ND | +a |
Adrenal gland | ++a | ++a | ND | −a |
Testis | +a | +1 | ND | +a |
Uterus | −a | −a | ND | +++a |
Expression of receptors NPBW1 or NPBW2: ND, not determined; –, not detected; +, low levels; ++, moderate levels; +++, high levels, as determined by
RT–PCR.
In situ hybridisation.
In vitro autoradiography or
Immunocytochemistry. These data are from Brezillon et al. (2003), Fujii et al. (2002), Lee et al. (1999), O'Dowd et al. (1995), Singh et al. (2004) and Tanaka et al. (2003).