Table 3.
CNS distribution of NPB and NPW in human, mouse and rat
| Human | Mouse | Rat | ||||
|---|---|---|---|---|---|---|
| NPB | NPW | NPB | NPW | NPB | NPW | |
| Cerebellum | ++a | ++a | −b | −b | +a | ND |
| Parietal cortex | +a | ++a | −b | −b | ND | ND |
| Hippocampus | ++a | ++a | ++b | −b | ++a,b | ND |
| Amygdala | ++a | ++a | −b | −b | ND | ++c |
| Hypothalamus | ++a | −a | +++b | −b | ++a,b | ++c |
| Thalamus | +a | −a | +b | −b | +a | ND |
| Caudate nucleus | +a | −a | −b | −b | ND | ND |
| Substantia nigra | +++a | +++a | −b | −b | ++c | ND |
| Corpus callosum | ++a | −a | −b | −b | ND | ND |
| Chorid plexus | +a | ++a | −b | −b | ND | ND |
| Periaqueductal grey | ND | ND | −b | ++b | ND | ND |
| Ventral tegmental area | ND | ND | −b | +b | ND | ++c |
| Dorsal raphe nuclei | ND | ND | −b | +++b | ++c | +++c |
| Edinger Westphal nuclei | ND | ND | +b | ++b | ++c | ND |
| Spinal cord | +++a | −a | ND | ND | +a | ND |
Expression of NPB or NPW: ND, not determined; −, not detected; +, low levels; ++, moderate levels; +++, high levels, as determined by
a
RT–PCR.
b
In situ hybridisation, or
c
Immunocytochemistry. These data are from Brezillon et al. (2003), Dun et al. (2005), Dun et al. (2003), Fujii et al. (2002), Singh et al. (2004) and Tanaka et al. (2003).