Table 1.

Behavioral effects of treatment with drugs during adolescence vs adulthood. Male data only.

Treatment	Measure	Results	Reference
COCAINE
Cocaine 4 days, PND 34–39, 60–70	Locomotor activity	Less sensitization in PA than AD	21
Cocaine PND 28–34, 60–66	Locomotor activity	PA: no sens; AD: sens	25
AMPHETAMINE
Amp	Locomotor activity	PA: sens only after PND49	29
Amp 30, 60	CPP	PA: no amp CPP; AD: amp CPP	30
NICOTINE
Nic 7 days PND 28, 60 Test 1 or 30 days later	Locomotor activity	PA: no sens; AD: sens	54; 55
Nic 7 days, inj PND 28–34, 90-96, Test 3 days later	Locomotor activity	PA: no sens; AD: sens	56
Nic 10 days, PND 28, 70	Locomotor activity, cue conditioning	PA: no sens, cue conditioning; AD: sens and cue conditioning	57
Nic continuous 21 days; PND 30, 60	Locomotor activity	PA, AD: NC during tx	89
Nic continuous 12 days: PND 25, 55	Locomotor activity	PA, AD: sens during tx	58
Nic continuous PND 30–47	Grooming	PA: no change; AD: decreased	59
Nic acute or chronic	Anxiety	Nic produced anxiety in PA but not in AD	63–65
Nic 7 days PND 28, 60 Test 1 or 30 days later	Locomotor activity	PA: sens to cocaine days 1 and 30; AD: sens to cocaine day 1 only	54
Nic 7 days PND 28, 60 Test 1 or 30 days later	Locomotor activity	PA: sens to amp; AD: no change	55
Nic 10 days – test 5 weeks later	Nic S-A	Increased after tx as PA	53
Nic PND 42–60	Self-administration	↑ fentanyl S-A	67
Nic PND 28, 38, 90	Nic CPP	CPP only at PND 28	62
Nic PND 28, 58 Test PND 40, 70	Nic CPP	CPP only in PA, not in AD	61
Nic PND 25–60 (mice) Tested 12 days later	Cocaine CPP	↓ CPP	68
Nic PND 35–44, Test PND 80	Cocaine CPP	↑ CPP	66

PA: periadolescent; AD: adult; sens: sensitization; Nic: nicotine; amp: amphetamine; CPP: conditioned place preference; S-A: self-administration; NC: no change