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. 2006 Dec 28;104(2):410–417. doi: 10.1073/pnas.0610770104

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© 2006 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 8. — Ciliated cells do not divide or transdifferentiate after SO₂ exposure. Shown are FOXJ1-CreER^2T; Rosa26R X-gal-stained 7-μm paraffin sections of the trachea. (A and B) Twenty-four hours after SO₂ inhalation. (A) Proximal trachea with SMG duct. Anti-BrdU (black) and X-gal (blue; arrows) do not colocalize. (B) Single confocal z-section of distal trachea. Anti-BrdU (red) and X-gal (black) do not colocalize. (C and D) Two weeks after SO₂ inhalation. Black, anti-β-tubulin; blue, X-gal. (C) Typical trachea section; ciliated cells have differentiated in the repaired epithelium but are not lineage-labeled. (D) Lineage-labeled cells have cilia (arrows). Domed Clara cells have not inherited the lineage label (arrowheads). (Scale bars: 20 μm.)