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Competitive binding of PH-PTB to phosphatidylinositides and inositol phosphates using [3H]dioctanoyl P(3,4,5)IP3 as tracer
| Competitor | IC50, μM | Competitor | IC50, μM |
|---|---|---|---|
| PI(3,4,5)P3 | 2.2 ± 0.6 | Ins(1,3,4,5)P4 | >100 |
| PI(4,5)P2 | 2.5 ± 0.3 | Ins(1,4,5)P3 | >100 |
| PI(3,4)P2 | 16.0 ± 6.3 | Ins(1,3,4)P3 | >100 |
| PI(4)P | 13.7 ± 3.4 | Ins(4)P | >100 |
| PI(3)P | >50 | — | — |
| PI | >50 | Myoinositol | >1000 |
